In a phase II (safety an_d efficacy) study sponsored by the developer, European researchers ran_domized 72 patients with mild-to-moderate hypertension to one of two doses of vaccine (100 or 300 μg) or to placebo. The vaccine consists of virus-lik_e particles linked to angiotensin II injections were given at weeks 0, 4, an_d 12.

By week 14, about 20% of vaccine recipients had experienced transient flu-lik_e symptoms, an_d all had antibodies against angiotensin II. Those who received the 300-μg regimen had significant dro_ps in mean BP compared with placebo recipients, especially early in the morning (–25 mm Hg systolic, –13 mm Hg diastolic).

Commentators wonder about the hazards of a treatment whose effects are not immediately reversible (the antibodys half-life after the third injection was 17 weeks). However, they find the exploratory trial "promising."

In a phase II (safety an_d efficacy) study sponsored by the developer, European researchers ran_domized 72 patients with mild-to-moderate hypertension to one of two doses of vaccine (100 or 300 μg) or to placebo

. در فاز دوم (اثر بخشی ایمنی an_d) مورد مطالعه با توسعه دهنده ، محققان اروپایی حمایت ran_domized 72 - خفیف بیماران مبتلا به فشار خون بالا در حد

متوسط را به یکی از دو دوز از واکسن (100 یا 300 میکروگرم) یا دارونما. The vaccine consists of virus-lik_e particles linked to angiotensin II injections were given at weeks 0, 4, an_d 12

. واکسن متشکل از ذرات ویروس - lik_e مرتبط با تزریق آنژیوتانسین در هفته دوم شد 0 داده شود ، 4 ، an_d 12.

By week 14, about 20% of vaccine recipients had experienced transient flu-lik_e symptoms, an_d all had antibodies against angiotensin II

. با 14 هفته ، حدود 20 درصد از دریافت کنندگان واکسن انفلوانزا گذرا - lik_e علائم را تجربه کرده بود ، تمام شده بود an_d آنتی بادی بر علیه آنژیوتانسین دوم

است. Those who received the 300-μg regimen had significant dro_ps in mean BP compared with placebo recipients, especially early in the morning (–25 mm Hg systolic, –13 mm Hg diastolic

). کسانی که موفق به دریافت 300 میکروگرم به حال رژیم dro_ps قابل توجهی در متوسط فشار خون در مقایسه با دریافت کنندگان پلاسبو ، به خصوص در اوایل صبح (-25 میلیمتر جیوه سیستولیک ، -13 میلی متر جیوه و دیاستولیک).

Commentators wonder about the hazards of a treatment whose effects are not immediately reversible (the

antibodys half-life after the third injection was 17 weeks). مفسران در مورد خطرات و اثرات درمان آنها به طور نیست فورا برگشت پذیر

(نیمه antibodys عمر پس از تزریق سوم 17 هفته بود تعجب). However, they find the exploratory trial "promising." با این حال ، آنها را

پیدا محاکمه اکتشافی "قول".